1w2k | pdb_00001w2k
TF7A_4380 COMPLEX
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| 1w2k, resolution 3.00Å | |||||||||||||
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| Sites: | AC1 | ||||||||||||
| Ligands: | FUC, BGC, CA, CAC and 380 | ||||||||||||
| Activity: | Coagulation factor VIIa, with EC number 3.4.21.21 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Overview
Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling.
Disease
Known diseases associated with this structure: Esophageal squamous cell carcinoma OMIM:[606551], Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]
About this Structure
1W2K is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:15664864
Page seeded by OCA on Thu Mar 20 14:51:12 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Coagulation factor VIIa
- Homo sapiens
- Protein complex
- Ackermann, J.
- Arcy, A D.
- Banner, D W.
- Groebke-Zbinden, K.
- Ji, Y.
- Kirchhofer, D.
- Tschopp, T B.
- Wallbaum, S.
- Weber, L.
- 380
- BGC
- CA
- CAC
- FUC
- Blood coagulation
- Calcium-binding
- Co-factor
- Coagulation
- Enzyme complex
- Gamma-carboxyglutamic acid
- Glycoprotein
- Hydrolase
- Plasma
- Serine protease
- Vitamin k
