2m45 | pdb_00002m45

NMR solution structure of the C-terminus of the minichromosome maintenance protein MCM from Sulfolobus solfataricus

spinqualitylabelsall models 2m45, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2m45 is a 1 chain structure with sequence from Sulso. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: MCM, SSO0774 (SULSO) Activity: DNA helicase, with EC number 3.6.4.12 Resources: FirstGlance, OCA, RCSB, PDBsum Function [MCM_SULSO] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.

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