1yw2 | pdb_00001yw2
Mutated Mus Musculus P38 Kinase (mP38)
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| 1yw2, resolution 2.01Å | |||||||||||||
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| Ligands: | PGJ | ||||||||||||
| Gene: | Mapk14, Crk1, Csbp1, Csbp2 (Mus musculus) | ||||||||||||
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Overview
4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-alpha) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induced TNF-alpha production.
About this Structure
1YW2 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production., Laughlin SK, Clark MP, Djung JF, Golebiowski A, Brugel TA, Sabat M, Bookland RG, Laufersweiler MJ, VanRens JC, Townes JA, De B, Hsieh LC, Xu SC, Walter RL, Mekel MJ, Janusz MJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2399-403. PMID:15837333
Page seeded by OCA on Thu Mar 20 15:28:13 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Mus musculus
- Non-specific serine/threonine protein kinase
- Single protein
- Bookland, R G.
- Brugel, T A.
- Clark, M P.
- De, B.
- Djung, J F.
- Golebiowski, A.
- Hsieh, L C.
- Janusz, M J.
- Laufersweiler, M J.
- Laughlin, S K.
- Mekel, M J.
- Sabat, M.
- Townes, J A.
- Vanrens, J C.
- Walter, R L.
- Xu, S C.
- PGJ
- Transferase
