1z10 | pdb_00001z10
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| 1z10, resolution 1.90Å | |||||||||||||
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| Ligands: | HEM, COU and GOL | ||||||||||||
| Gene: | CYP2A6 (Homo sapiens) | ||||||||||||
| Activity: | Unspecific monooxygenase, with EC number 1.14.14.1 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal Structure of Human Microsomal P450 2A6 with Coumarin Bound
Overview
Human microsomal cytochrome P450 2A6 (CYP2A6) contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. The CYP2A6 structure shows a compact, hydrophobic active site with one hydrogen bond donor, Asn297, that orients coumarin for regioselective oxidation. The inhibitor methoxsalen effectively fills the active site cavity without substantially perturbing the structure. The structure should aid the design of inhibitors to reduce smoking and tobacco-related cancers.
Disease
Known diseases associated with this structure: Coumarin resistance OMIM:[122720], Lung cancer, resistance to OMIM:[122720], Nicotine addiction, protection from OMIM:[122720]
About this Structure
1Z10 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen., Yano JK, Hsu MH, Griffin KJ, Stout CD, Johnson EF, Nat Struct Mol Biol. 2005 Sep;12(9):822-3. Epub 2005 Aug 7. PMID:16086027
Page seeded by OCA on Thu Mar 20 15:29:59 2008
