4f42 | pdb_00004f42

Neurotrophin p75NTR intracellular domain

spinqualitylabelsall models 4f42, resolution 2.38Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4f42 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MNB Related: 4f44 Gene: Ngfr, NM_012610, Tnfrsf16 (Rattus norvegicus) Resources: FirstGlance, OCA, RCSB, PDBsum Function [TNR16_RAT] Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.

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