4ot8 | pdb_00004ot8

X-ray Crystal Structure of Serine Hydroxymethyl Transferase from Burkholderia cenocepacia bound to PLP and Serine

spinqualitylabelsall models 4ot8, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ot8 is a 4 chain structure with sequence from Burcj. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: PLP, SER Related: 4mso, 4n0w, 4otl Gene: glyA, BCAL3197 (BURCJ) Activity: Glycine hydroxymethyltransferase, with EC number 2.1.2.1 Resources: FirstGlance, OCA, RCSB, PDBsum Function [B4ECY9_BURCJ] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).[HAMAP-Rule:MF_00051] See Also Serine hydroxymethyltransferase

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