1zxc | pdb_00001zxc
Crystal structure of catalytic domain of TNF-alpha converting enzyme (TACE) with inhibitor
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| 1zxc, resolution 2.28Å | |||||||||||||
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| Ligands: | ZN and IH6 | ||||||||||||
| Gene: | ADAM17, CSVP, TACE (Homo sapiens) | ||||||||||||
| Activity: | ADAM 17 endopeptidase, with EC number 3.4.24.86 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Overview
The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors bearing a butynyloxy P1' group was explored. In particular, compound 5k has excellent in vitro potency against TACE enzyme and in cells, and oral activity in an in vivo model of TNF-alpha production and a collagen-induced arthritis model.
About this Structure
1ZXC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates., Levin JI, Chen JM, Laakso LM, Du M, Du X, Venkatesan AM, Sandanayaka V, Zask A, Xu J, Xu W, Zhang Y, Skotnicki JS, Bioorg Med Chem Lett. 2005 Oct 1;15(19):4345-9. PMID:16084720
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