4mec | pdb_00004mec

Crystal structure of RAT Heme oxygenase-1 in complex with ZN(II)-Protoporphyrin IX

spinqualitylabelsall models 4mec, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4mec is a 7 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ZNH Activity: Heme oxygenase, with EC number 1.14.99.3 Resources: FirstGlance, OCA, RCSB, PDBsum Function [HMOX1_RAT] Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.

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