4iio | pdb_00004iio

Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide

spinqualitylabelsall models 4iio, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4iio is a 3 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, SO4, UNX NonStd Res: ACE Gene: ITSN2, KIAA1256, SH3D1B, SWAP (HUMAN) Resources: FirstGlance, OCA, RCSB, PDBsum Function [ITSN2_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).

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