2c0t | pdb_00002c0t
From Proteopedia
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| 2c0t, resolution 2.15Å | |||||||||||||
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| Sites: | AC1 | ||||||||||||
| Ligands: | CA and L3G | ||||||||||||
| Activity: | Transferred entry: 2.7.10.1 and 2.7.10.2, with EC number 2.7.1.112 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359
Overview
We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.
About this Structure
2C0T is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection., Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF, Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10. PMID:16216497
Page seeded by OCA on Thu Mar 20 16:09:24 2008
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Single protein
- Transferred entry: 2 7.10 1 and 2 7.10 2
- Borhani, D W.
- Burchat, A.
- Calderwood, D J.
- Hirst, G C.
- Li, B.
- Loew, A.
- CA
- L3G
- Alternative initiation
- Atp-binding
- Kinase
- Lipoprotein
- Myristate
- Nucleotide-binding
- Palmitate
- Phosphorylation
- Sh2 domain
- Sh3 domain
- Transferase
- Tyrosine-protein kinase
