Structural highlights
4kpd is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | IPE, MG, RIS |
| Related: | 4kfa, 4kpj, 4kq5, 4kqs, 4kqu |
| Gene: | FDPS, FPS, KIAA1293 (HUMAN) |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Function
[FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
