3snm | pdb_00003snm

Crystal structure of a lectin from Canavalia maritima seeds complexed with Indole-3-Acetic Acid

spinqualitylabelsall models 3snm, resolution 2.15Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3snm is a 1 chain structure with sequence from Canavalia lineata. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA, IAC, IND, MN Resources: FirstGlance, OCA, RCSB, PDBsum Function [CONA_CANLI] Glucose/D-mannose specific lectin. Publication Abstract from PubMed Indole-3-acetic acid (IAA) bound is considered a storage molecule and is inactive. However, some studies have proposed an additional possible regulatory mechanism based on the ability of lectins to form complexes with IAA. We report the first crystal structure of ConM in complex with IAA at 2.15 A resolution. Based on a tetrameric model of the complex, we hypothesize how the lectin controls the availability of IAA during the early seedling stages, indicating a possible new physiological role for these proteins. A free indole group is also bound to the protein. The ConM interaction with different forms of IAA is a strategy to render the phytohormone unavailable to the cell. Thus, this new physiological role proposed for legume lectins might be a novel mechanism by which IAA levels are decreased in addition to the destruction and formation of new complexes in the later stages of seed germination. Interactions between indole-3-acetic acid (IAA) with a lectin from Canavalia maritima seeds reveal a new function for lectins in plant physiology.,Delatorre P, Silva-Filho JC, Rocha BA, Santi-Gadelha T, da Nobrega RB, Gadelha CA, do Nascimento KS, Nagano CS, Sampaio AH, Cavada BS Biochimie. 2013 Sep;95(9):1697-703. doi: 10.1016/j.biochi.2013.05.008. Epub 2013 , May 29. PMID:23727478 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Concanavalin A

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