3a98 | pdb_00003a98

Crystal structure of the complex of the interacting regions of DOCK2 and ELMO1

spinqualitylabelsall models 3a98, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3a98 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: MSE Gene: DOCK2, KIAA0209 (Homo sapiens), ELMO1, KIAA0281 (Homo sapiens) Resources: FirstGlance, OCA, RCSB, PDBsum Function [ELMO1_HUMAN] Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

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