2dsk | pdb_00002dsk
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| 2dsk, resolution 1.50Å | |||||||||||||
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| Ligands: | SO4 and GOL | ||||||||||||
| Activity: | Chitinase, with EC number 3.2.1.14 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of catalytic domain of hyperthermophilic chitinase from Pyrococcus furiosus
Overview
The crystal structure of the catalytic domain of a chitinase from the hyperthermophilic archaeon Pyrococcus furiosus (AD2(PF-ChiA)) has been determined at 1.5 A resolution. This is the first structure of the catalytic domain of an archaeal chitinase. The overall structure of AD2(PF-ChiA) is a TIM-barrel fold with a tunnel-like active site that is a common feature of family 18 chitinases. Although the catalytic residues (Asp522, Asp524 and Glu526) are conserved, comparison of the conserved residues and structures with those of other homologous chitinases indicates that the catalytic mechanism of PF-ChiA is different from that of family 18 chitinases.
About this Structure
2DSK is a Single protein structure of sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA.
Reference
Structure of the catalytic domain of the hyperthermophilic chitinase from Pyrococcus furiosus., Nakamura T, Mine S, Hagihara Y, Ishikawa K, Uegaki K, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jan 1;63(Pt, 1):7-11. Epub 2006 Dec 16. PMID:17183162
Page seeded by OCA on Thu Mar 20 16:31:03 2008
