1af9 | pdb_00001af9

TETANUS NEUROTOXIN C FRAGMENT

spinqualitylabelsall models 1af9, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1af9 is a 1 chain structure with sequence from Clostridium tetani. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Activity: Tentoxilysin, with EC number 3.4.24.68 Resources: FirstGlance, OCA, RCSB, PDBsum Function [TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The 2.7 A structure of the tetanus neurotoxin receptor binding fragment Hc reveals a jelly-roll domain and a beta-trefoil domain. Hc retains the unique transport properties of the holotoxin and is capable of eliciting a protective immunological response against the full length holotoxin. Structure of the receptor binding fragment HC of tetanus neurotoxin.,Umland TC, Wingert LM, Swaminathan S, Furey WF, Schmidt JJ, Sax M Nat Struct Biol. 1997 Oct;4(10):788-92. PMID:9334741 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Tetanus toxin

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