2dz7 | pdb_00002dz7
DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)
| |||||||||||||
| 2dz7, resolution 1.60Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | MG | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Overview
The crystal structure of the tetragonal form of d(gcGAAAgc) has been revised and reasonably refined including the disordered residues. The two DNA strands form a base-intercalated duplex, and the four duplexes are assembled according to the crystallographic 222 symmetry to form an octaplex. In the central region, the eight strands are associated by I-motif of double A-quartets. Furthermore, eight hydrated-magnesium cations link the four duplexes to support the octaplex formation. Based on these structural features, a proposal that folding of d(GAAA)n, found in the non-coding region of genomes, into an octaplex can induce slippage during replication to facilitate length polymorphism is presented.
About this Structure
2DZ7 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem. 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:17062599
Page seeded by OCA on Thu Mar 20 16:33:19 2008
