2pq8 | pdb_00002pq8

MYST histone acetyltransferase 1

spinqualitylabelsall models 2pq8, resolution 1.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2pq8 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: COA, UNX, ZN Gene: MYST1, MOF, PP7073 (Homo sapiens) Activity: Histone acetyltransferase, with EC number 2.3.1.48 Resources: FirstGlance, OCA, RCSB, PDBsum Function [MYST1_HUMAN] Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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