3t95 | pdb_00003t95

Crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2

spinqualitylabelsall models 3t95, resolution 1.75Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3t95 is a 1 chain structure with sequence from Yersinia pestis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: PAV Related: 1tjy, 3ejw, 1tm2 Gene: lsrB, y3772, YPO0409, YP_3772 (Yersinia pestis) Resources: FirstGlance, OCA, RCSB, PDBsum Function [LSRB_YERPE] Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity). Publication Abstract from PubMed The crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2 (AI-2; space group P2(1)2(1)2(1), unit-cell parameters a = 40.61, b = 61.03, c = 125.23 A) has been solved by molecular replacement using the structure of LsrB from Salmonella typhimurium (PDB entry 1tjy) and refined to R = 0.180 (R(free) = 0.213) at 1.75 A resolution. The electron density for bound AI-2 and the stereochemistry of the AI-2-binding site are consistent with bound AI-2 adopting the (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran conformation, just as has been observed in the crystal structures of the Salmonella typhimurium and Sinorhizobium meliloti LsrB-AI-2 complexes. The structure of LsrB from Yersinia pestis complexed with autoinducer-2.,Kavanaugh JS, Gakhar L, Horswill AR Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1501-5., Epub 2011 Nov 29. PMID:22139152 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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