3raw | pdb_00003raw

Crystal Structure of human CDC-like kinase 3 isoform in complex with leucettine L41

spinqualitylabelsall models 3raw, resolution 2.09Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3raw is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 3RA Related: 2eu9 Gene: CLK3 (Homo sapiens) Activity: Dual-specificity kinase, with EC number 2.7.12.1 Resources: FirstGlance, OCA, RCSB, PDBsum Function [CLK3_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. See Also Dual specificity protein kinase

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