2ffh | pdb_00002ffh
THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS
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| 2ffh, resolution 3.2Å | |||||||||||||
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| Ligands: | CD and SO4 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Overview
The crystal structure of the signal sequence binding subunit of the signal recognition particle (SRP) from Thermus aquaticus reveals a deep groove bounded by a flexible loop and lined with side chains of conserved hydrophobic residues. The groove defines a flexible, hydrophobic environment that is likely to contribute to the structural plasticity necessary for SRP to bind signal sequences of different lengths and amino acid sequence. The structure also reveals a helix-turn-helix motif containing an arginine-rich alpha helix that is required for binding to SRP RNA and is implicated in forming the core of an extended RNA binding surface.
About this Structure
2FFH is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the signal sequence binding subunit of the signal recognition particle., Keenan RJ, Freymann DM, Walter P, Stroud RM, Cell. 1998 Jul 24;94(2):181-91. PMID:9695947
Page seeded by OCA on Thu Mar 20 16:51:46 2008
