Exoenzyme

spinqualitylabelsall models Structure of exoenzyme C3 catalytic domain complex with ADP and NAD (PDB code 2c8c). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Exoenzymes (Exo) are secreted by cells and break large macromolecules outside the cells. The breakdown components can pass through the cell wall. Exo C3 is a Clostridium butulinum toxin which binds NAD, splits it into ADP-ribose and nicotinamide and transfers the ADP-ribose to a protein substrate. Exo S and Exo T are secreted by Pseudomonas aeruginosa and has GTPase-activating activity as well as ADP-ribosyltransferase activity.

3D structures of exoenzyme

Updated on 28-December-2014

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• Exoenzyme C3
  • 1g24 – CbExo residues 8-218 – Clostridium butulinum
    
  • 1uzi, 1r45, 1r4b, 2c89 – CbExo catalytic domain
    
  • 1gze, 2c8b, 2c8d, 2c8e, 2c8g – CbExo catalytic domain (mutant)
    
  • 3bw8 - Exo catalytic domain - Clostridium limosum
    
• Exoenzyme C3 complexes
  • 1gzf – CbExo catalytic domain + pyridinium derivative + ADP + NAD
    
  • 2bov – CbExo + GDP + Ral-A GTPase
    
  • 2a78 – CbExo catalytic domain + GDP + Ral-A GTPase
    
  • 2a9k – CbExo catalytic domain+ GDP + Ral-A GTPase + NAD
    
  • 2c8a – CbExo catalytic domain + nicotinamide
    
  • 2c8c – CbExo catalytic domain (mutant) + ADP + NAD
    
  • 2c8f, 2c8h – CbExo catalytic domain (mutant) + NAD
    
• Exoenzyme S
  • 1r4t – PaExo GAP domain – Pseudomonas aeruginosa - NMR
    
  • 1he1 – PaExo GAP domain + Ras-like protein + GDP
    
  • 1he9 – PaExo GAP domain + Ras-like protein
    
• Exoenzyme T
  • 4jmf – PaExo residues 28-77 + chaperone
    

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Michal Harel, Alexander Berchansky