RiAFP
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The asymmetric unit comprises two RiAFP molecules juxtaposed with their ice-binding surfaces, however the protein is monomer in the solutio
Overall StructureThe crystallographic structure of RiAFP was defined recently[3]. It reveals a new β-solenoid architecture that forms β-sandwich of two parallel 6 and 7 stranded-sheets of remarkable regularity. The β-sheets lie on top of each other with the upper and lower strands parallel but in the opposite orientation. Two ends deviate from β helix regularity by forming capping structures. These capping structures help to prevent end-to-end associations that would spoil the solubility of RiAFP and lead to oligomerization and aggregation. FunctionDiseaseRelevanceStructural highlightsThis is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. The three residues in �-strand 11 at the C terminus (Gln110, Gln112, and Ile114) that are too bulky to be accommodated into the core may also contribute to the capping structure to prevent amyloid-like polymerization. Within the core there are hydrogen bonds between Thr-Ser (65-55, 85-75, 132-124 respectively) and one disulfide bond between Cys4-Cys21, that contributes to stabilize the whole structure.
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