RiAFP
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The asymmetric unit comprises two RiAFP molecules juxtaposed with their ice-binding surfaces, however the protein is monomer in the solutio
Overall StructureThe crystallographic structure of RiAFP was defined recently[3]. It reveals a new β-solenoid architecture that forms β-sandwich of two parallel 6 and 7 stranded-sheets of remarkable regularity. The β-sheets lie on top of each other with the upper and lower strands parallel but in the opposite orientation. Two ends deviate from β helix regularity by forming capping structures. These capping structures help to prevent end-to-end associations that would spoil the solubility of RiAFP and lead to oligomerization and aggregation. The three residues in β-strand 11 at the C terminus (Gln110, Gln112, and Ile114) that are too bulky to be accommodated into the core may also contribute to the capping structure to prevent amyloid-like polymerization.
FunctionDiseaseRelevanceStructural highlightsThis is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
Within the core there are hydrogen bonds between Thr-Ser (65-55, 85-75, 132-124 respectively) and one disulfide bond between Cys4-Cys21, that contributes to stabilize the whole structure. another way to show the bonds
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