463d | pdb_0000463d

CALCIUM FORM OF D(CGCGAATTCGCG)2

spinqualitylabelsall models 463d, resolution 1.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 463d is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The dodecamer d(CGCGAATTCGCG) was the first oligonucleotide to be crystallized as a B-DNA duplex. Its structure was analyzed in detail in the early 1980s. Here we show that, in the presence of Ca(2+), it crystallizes in a different way (R3 space group). The dodecamers form parallel columns of straight duplexes with ten base pairs in the B form. The terminal cytosines in each molecule are disordered, whereas the terminal guanines are placed in the minor groove of neighbor duplexes. The central GAATTC region is practically identical to that found in the classic structure of the same dodecamer crystallized in the P2(1)2(1)2(1) space group in the presence of Mg(2+) and spermine. Its structure is thus independent of the crystallization conditions which have been used. Structure of d(CGCGAATTCGCG) in the presence of Ca(2+) ions.,Liu J, Subirana JA J Biol Chem. 1999 Aug 27;274(35):24749-52. PMID:10455145 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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