3viu | pdb_00003viu

Crystal structure of PurL from thermus thermophilus

spinqualitylabelsall models 3viu, resolution 2.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3viu is a 1 chain structure with sequence from Thermus thermophilus. This structure supersedes the now removed PDB entry 3ac6. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ADP, MG, PEG, PO4 NonStd Res: MSE Gene: purL, TTHA1519 (Thermus thermophilus) Activity: Phosphoribosylformylglycinamidine synthase, with EC number 6.3.5.3 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The crystal structure of PurL from Thermus thermophilus HB8 (TtPurL; TTHA1519) was determined in complex with an adenine nucleotide, PO(4)(3-) and Mg(2+) at 2.35 A resolution. TtPurL consists of 29 alpha-helices and 28 beta-strands, and one loop is disordered. TtPurL consists of four domains, A1, A2, B1 and B2, and the structures of the A1-B1 and A2-B2 domains were almost identical to each other. Although the sequence identity between TtPurL and PurL from Thermotoga maritima (TmPurL) is higher than that between TtPurL and the PurL domain of the large PurL from Salmonella typhimurium (StPurL), the secondary structure of TtPurL is much more similar to that of StPurL than to that of TmPurL. Structure of N-formylglycinamide ribonucleotide amidotransferase II (PurL) from Thermus thermophilus HB8.,Suzuki S, Yanai H, Kanagawa M, Tamura S, Watanabe Y, Fuse K, Baba S, Sampei G, Kawai G Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jan 1;68(Pt 1):14-9. Epub , 2011 Dec 24. PMID:22232163 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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