3uh8 | pdb_00003uh8

N-terminal domain of phage TP901-1 ORF48

spinqualitylabelsall models 3uh8, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3uh8 is a 1 chain structure with sequence from Bacteriophage tp901-1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 3ejc, 2f0c, 3u6x Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Phages of the Caudovirales order possess a tail that recognizes the host and ensures genome delivery upon infection. The X-ray structure of the approximately 1.8 MDa host adsorption device (baseplate) from the lactococcal phage TP901-1 shows that the receptor-binding proteins are pointing in the direction of the host, suggesting that this organelle is in a conformation ready for host adhesion. This result is in marked contrast with the lactococcal phage p2 situation, whose baseplate is known to undergo huge conformational changes in the presence of Ca(2+) to reach its active state. In vivo infection experiments confirmed these structural observations by demonstrating that Ca(2+) ions are required for host adhesion among p2-like phages (936-species) but have no influence on TP901-1-like phages (P335-species). These data suggest that these two families rely on diverse adhesion strategies which may lead to different signaling for genome release. Structure of the phage TP901-1 1.8 MDa baseplate suggests an alternative host adhesion mechanism.,Veesler D, Spinelli S, Mahony J, Lichiere J, Blangy S, Bricogne G, Legrand P, Ortiz-Lombardia M, Campanacci V, van Sinderen D, Cambillau C Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8954-8. Epub 2012 May 18. PMID:22611190 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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