4eo2 | pdb_00004eo2

Structure of the bacteriophage C1 tail knob protein, gp12

spinqualitylabelsall models 4eo2, resolution 3.01Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4eo2 is a 6 chain structure with sequence from Streptococcus phage c1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 4ep0 Gene: orf12 (Streptococcus phage C1) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The Podoviridae phage C1 was one of the earliest isolated bacteriophages and the first virus documented to be active against streptococci. The icosahedral and asymmetric reconstructions of the virus were calculated using cryo-electron microscopy. The capsid protein has an HK97 fold arranged into a T = 4 icosahedral lattice. The C1 tail is terminated with a varphi29-like knob, surrounded by a skirt of twelve long appendages with novel morphology. Several C1 structural proteins have been identified, including a candidate for an appendage. The crystal structure of the knob has an N-terminal domain with a fold observed previously in tube forming proteins of Siphoviridae and Myoviridae phages. The structure of C1 suggests the mechanisms by which the virus digests the cell wall and ejects its genome. Although there is little sequence similarity to other phages, conservation of the structural proteins demonstrates a common origin of the head and tail, but more recent evolution of the appendages. Structural investigations of a Podoviridae streptococcus phage C1, implications for the mechanism of viral entry.,Aksyuk AA, Bowman VD, Kaufmann B, Fields C, Klose T, Holdaway HA, Fischetti VA, Rossmann MG Proc Natl Acad Sci U S A. 2012 Aug 13. PMID:22891295 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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