4eqm | pdb_00004eqm

Structural analysis of Staphylococcus aureus serine/threonine kinase PknB

spinqualitylabelsall models 4eqm, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4eqm is a 6 chain structure with sequence from Staphylococcus aureus subsp. aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ANP, BEN Gene: SA1063 (Staphylococcus aureus subsp. aureus) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Effective treatment of infections caused by the bacterium Staphylococcus aureus remains a worldwide challenge, in part due to the constant emergence of new strains that are resistant to antibiotics. The serine/threonine kinase PknB is of particular relevance to the life cycle of S. aureus as it is involved in the regulation of purine biosynthesis, autolysis, and other central metabolic processes of the bacterium. We have determined the crystal structure of the kinase domain of PknB in complex with a non-hydrolyzable analog of the substrate ATP at 3.0 A resolution. Although the purified PknB kinase is active in solution, it crystallized in an inactive, autoinhibited state. Comparison with other bacterial kinases provides insights into the determinants of catalysis, interactions of PknB with ligands, and the pathway of activation. Structural Analysis of Staphylococcus aureus Serine/Threonine Kinase PknB.,Rakette S, Donat S, Ohlsen K, Stehle T PLoS One. 2012;7(6):e39136. Epub 2012 Jun 11. PMID:22701750 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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