4p8s | pdb_00004p8s

Crystal structure of Nogo-receptor-2

spinqualitylabelsall models 4p8s, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4p8s is a 1 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NDG Related: 1ozn, 4p91 Gene: Rtn4rl2, Ngrh1 (Buffalo rat) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The inhibition of axon regeneration upon mechanical injury is dependent on interactions between Nogo receptors (NgRs) and their myelin-derived ligands. NgRs are composed of a leucine-rich repeat (LRR) region, thought to be structurally similar among the different isoforms of the receptor, and a divergent "stalk" region. It has been shown by others that the LRR and stalk regions of NgR1 and NgR2 have distinct roles in conferring binding affinity to the myelin associated glycoprotein (MAG) in vivo. Here, we show that purified recombinant full length NgR1 and NgR2 maintain significantly higher binding affinity for purified MAG as compared to the isolated LRR region of either NgR1 or NgR2. We also present the crystal structure of the LRR and part of the stalk regions of NgR2 and compare it to the previously reported NgR1 structure with respect to the distinct signaling properties of the two receptor isoforms. Crystal structure of the Nogo-receptor-2.,Semavina M, Saha N, Kolev MV, Goldgur Y, Giger RJ, Himanen JP, Nikolov DB Protein Sci. 2011 Apr;20(4):684-9. doi: 10.1002/pro.597. PMID:21308849 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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