4mt0 | pdb_00004mt0

Crystal Structure of the Open State of the Neisseria gonorrhoeae MtrE Outer Membrane Channel

spinqualitylabelsall models 4mt0, resolution 3.29Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4mt0 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4 Related: 4msy, 4msz, 4mt1, 4mt3, 4mt4 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Active efflux of antimicrobial agents is one of the most important strategies used by bacteria to defend against antimicrobial factors present in their environment. Mediating many cases of antibiotic resistance are transmembrane efflux pumps, composed of one or more proteins. The Neisseria gonorrhoeae MtrCDE tripartite multidrug efflux pump, belonging to the hydrophobic and amphiphilic efflux resistance-nodulation-cell division (HAE-RND) family, spans both the inner and outer membranes of N. gonorrhoeae and confers resistance to a variety of antibiotics and toxic compounds. We here describe the crystal structure of N. gonorrhoeae MtrE, the outer membrane component of the MtrCDE tripartite multidrug efflux system. This trimeric MtrE channel forms a vertical tunnel extending down contiguously from the outer membrane surface to the periplasmic end, indicating that our structure of MtrE depicts an open conformational state of this channel. Crystal structure of the open state of the Neisseria gonorrhoeae MtrE outer membrane channel.,Lei HT, Chou TH, Su CC, Bolla JR, Kumar N, Radhakrishnan A, Long F, Delmar JA, Do SV, Rajashankar KR, Shafer WM, Yu EW PLoS One. 2014 Jun 5;9(6):e97475. doi: 10.1371/journal.pone.0097475. eCollection , 2014. PMID:24901251 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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