2j34 | pdb_00002j34
CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX
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| 2j34, resolution 2.01Å | |||||||||||||
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| Sites: | AC1 | ||||||||||||
| Ligands: | CA and GS6 | ||||||||||||
| Activity: | Coagulation factor Xa, with EC number 3.4.21.6 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Overview
Torsional scans of sulfonamide S-C bonds in small model systems of a series of arylsulfonamide factor Xa inhibitors were performed in order to investigate if conformational effects can help to rationalise the observed SAR. Computational results were in good agreement with the experimental data indicating that the sulfonamide conformation plays an important role in determining the activity in this particular series of factor Xa inhibitors.
Disease
Known disease associated with this structure: Factor X deficiency OMIM:[227600]
About this Structure
2J34 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Arylsulfonamides: a study of the relationship between activity and conformational preferences for a series of factor Xa inhibitors., Senger S, Convery MA, Chan C, Watson NS, Bioorg Med Chem Lett. 2006 Nov 15;16(22):5731-5. Epub 2006 Sep 18. PMID:16982192
Page seeded by OCA on Thu Mar 20 17:36:37 2008
