2ki5 | pdb_00002ki5

HERPES SIMPLEX TYPE-1 THYMIDINE KINASE IN COMPLEX WITH THE DRUG ACICLOVIR AT 1.9A RESOLUTION

File:2ki5.gif

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2ki5, resolution 1.90Å
Ligands:	SO4 and AC2
Gene:	TK (Human herpesvirus 4)
Activity:	Thymidine kinase, with EC number 2.7.1.21
Coordinates:	save as pdb, mmCIF, xml

Overview

Treatment of herpes infections with nucleoside analogues requires as an initial step the activation of the compounds by thymidine kinase. As an aid to developing more effective chemotherapy, both for treatment of recurrent herpes infection and in gene therapy systems where thymidine kinase is expressed, two high-resolution X-ray structures of thymidine kinase have been compared: one with the relatively poor substrate aciclovir (Zovirax), the other with a synthetic inhibitor having an N2-substituted guanine. Both compounds have similar binding modes in spite of their size difference and apparently distinct ligand properties.

About this Structure

2KI5 is a Single protein structure of sequence from Human herpesvirus 4. This structure supersedes the now removed PDB entry 1KI5. Full crystallographic information is available from OCA.

Reference

Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir., Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR, FEBS Lett. 1999 Jan 25;443(2):121-5. PMID:9989588

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