4k8x | pdb_00004k8x

Binary complex of 9N DNA polymerase in the replicative state

spinqualitylabelsall models 4k8x, resolution 2.28Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4k8x is a 3 chain structure with sequence from Thermococcus sp. 9on-7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 5CY, CL, EDO, SO4 NonStd Res: DOC Related: 1qht, 4k8z Gene: pol, polA (Thermococcus sp. 9oN-7) Activity: DNA-directed DNA polymerase, with EC number 2.7.7.7 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Replicate it: Structures of KOD and 9 degrees N DNA polymerases, two enzymes that are widely used to replicate DNA with highly modified nucleotides, were solved at high resolution in complex with primer/template duplex. The data elucidate substrate interaction of the two enzymes and pave the way for further optimisation of the enzymes and substrates. Structures of KOD and 9 degrees N DNA Polymerases Complexed with Primer Template Duplex.,Bergen K, Betz K, Welte W, Diederichs K, Marx A Chembiochem. 2013 Jun 17;14(9):1058-62. doi: 10.1002/cbic.201300175. Epub 2013, Jun 3. PMID:23733496 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also DNA polymerase

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