2opy | pdb_00002opy
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| 2opy, resolution 2.8Å | |||||||||||||
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| Ligands: | ZN and CO9 | ||||||||||||
| Gene: | BIRC4, API3, IAP3, XIAP (Homo sapiens) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Smac mimic bound to BIR3-XIAP
Overview
A small series of peptide mimics was designed and synthesized to contain a heterocyclic ring in place of the potentially labile N-terminal peptide bond of the tetrapeptide containing the Smac-XIAP-binding motif. Two Smac mimics were shown to bind to the BIR3 domain of XIAP with moderate affinity and one displayed increased activity in cells relative to the Smac peptides. The structures of BIR3-XIAP in complex with a Smac peptide and a peptide mimic were solved and analyzed to elucidate the structure-activity relationship surrounding the Smac-binding domain within BIR3-XIAP.
Disease
Known diseases associated with this structure: Lymphoproliferative syndrome, X-linked, 2 OMIM:[300079]
About this Structure
2OPY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP., Wist AD, Gu L, Riedl SJ, Shi Y, McLendon GL, Bioorg Med Chem. 2007 Apr 15;15(8):2935-43. Epub 2007 Feb 11. PMID:17336535
Page seeded by OCA on Thu Mar 20 18:02:56 2008
