4elt | pdb_00004elt

Snapshot of the large fragment of DNA polymerase I from Thermus Aquaticus processing modified pyrimidines

spinqualitylabelsall models 4elt, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4elt is a 3 chain structure with sequence from Thermus aquaticus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 0R5, ACT, EDO, GOL, MG NonStd Res: DOC Related: 3ojs, 3oju, 4elu, 4elv Gene: polA, pol1 (Thermus aquaticus) Activity: DNA-directed DNA polymerase, with EC number 2.7.7.7 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Modified nucleotides play a paramount role in many cutting-edge biomolecular techniques. The present structural study highlights the plasticity and flexibility of the active site of a DNA polymerase while incorporating non-polar "Click-able" nucleotide analogs and emphasizes new insights into rational design guidelines for modified nucleotides. Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site.,Obeid S, Busskamp H, Welte W, Diederichs K, Marx A Chem Commun (Camb). 2012 Aug 28;48(67):8320-2. Epub 2012 Jul 6. PMID:22766607 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also DNA polymerase

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