4opb | pdb_00004opb

AA13 Lytic polysaccharide monooxygenase from Aspergillus oryzae

spinqualitylabelsall models 4opb, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4opb is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ACT, CU, GOL, IPA, NAG, ZN NonStd Res: HIC Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Lytic polysaccharide monooxygenases (LPMOs) are recently discovered enzymes that oxidatively deconstruct polysaccharides. LPMOs are fundamental in the effective utilization of these substrates by bacteria and fungi; moreover, the enzymes have significant industrial importance. We report here the activity, spectroscopy and three-dimensional structure of a starch-active LPMO, a representative of the new CAZy AA13 family. We demonstrate that these enzymes generate aldonic acid-terminated malto-oligosaccharides from retrograded starch and boost significantly the conversion of this recalcitrant substrate to maltose by beta-amylase. The detailed structure of the enzyme's active site yields insights into the mechanism of action of this important class of enzymes. Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase.,Lo Leggio L, Simmons TJ, Poulsen JC, Frandsen KE, Hemsworth GR, Stringer MA, von Freiesleben P, Tovborg M, Johansen KS, De Maria L, Harris PV, Soong CL, Dupree P, Tryfona T, Lenfant N, Henrissat B, Davies GJ, Walton PH Nat Commun. 2015 Jan 22;6:5961. doi: 10.1038/ncomms6961. PMID:25608804 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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