4jn2 | pdb_00004jn2

An Antidote for Dabigatran

spinqualitylabelsall models 4jn2, resolution 1.71Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4jn2 is a 4 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 4CC, GOL Related: 4jn1 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Key points We present an antidote for dabigatran that effectively reverses its anticoagulative effect in human plasma in vitro and in rats in vivo.The antidote shares structural features with thrombin in the mode of binding, but has no activity in coagulation tests. A specific antidote for dabigatran: functional and structural characterization.,Schiele F, van Ryn J, Canada K, Newsome C, Sepulveda E, Park J, Nar H, Litzenburger T Blood. 2013 Mar 8. PMID:23476049 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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