2qqd | pdb_00002qqd
| |||||||||||||
| 2qqd, resolution 2.00Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sites: | AC1, AC2, AC3, AC4, AC5 and AC6 | ||||||||||||
| Ligands: | AG2, PYR and MPD | ||||||||||||
| Gene: | pdaD (Methanocaldococcus jannaschii) | ||||||||||||
| Activity: | Arginine decarboxylase, with EC number 4.1.1.19 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
N47A mutant of Pyruvoyl-dependent Arginine Decarboxylase from Methanococcus jannashii
Overview
Human deoxycytidine kinase (dCK) is involved in the nucleotide-biosynthesis salvage pathway and has also been shown to phosphorylate several antitumor and antiviral prodrugs. The structures of dCK alone and the dead-end complex of dCK with substrate nucleoside and product ADP or UDP have previously been reported; however, there is currently no structure available for a substrate or product complex. Here, the structures of dCK complexes with the products dCMP, UDP and Mg2+ ion, and with dAMP, UDP and Mg2+ ion are reported. Structural comparisons show that the product complexes with UDP and a dead-end complex with substrate and UDP have similar active-site conformations.
About this Structure
2QQD is a Protein complex structure of sequences from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.
Reference
Structures of human deoxycytidine kinase product complexes., Soriano EV, Clark VC, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1201-7. Epub 2007, Nov 16. PMID:18084067
Page seeded by OCA on Thu Mar 20 18:28:34 2008
