Cyclin

Cyclin (CYC) activate CYC-dependent kinase (CDK) thus acting in the control of the cell cycle. The CYC name derives from the fact that their concentration varies during the cell cycle. Among the CYCs, CYCA are active in the S phase, CYCD regulate the transition from G1 to S. See also Intrinsically Disordered Protein.

3D Structures of Cyclin

Updated on 18-March-2015

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• CYCA2
  • 3my5, 2wpa, 2wxv, 2wih, 2wip, 3f5x, 3eoc, 3eid, 3ej1, 3dog, 3ddp, 3ddq, 3bht, 2v22, 2uue, 2i40, 2bkz, 2c5n, 2c5o, 2c5v, 2c5x, 2c5y, 2bpm, 2c4g, 1fvv, 2c6t – hCYCA2 +CDK2+inhibitor - human
    
  • 3bhu, 3bhv, 2uzd, 2uzb, 2uze, 2uzl, 2uzn, 2uzo, 2iw6, 2iw8, 2iw9, 2g9x, 1oi9, 1oiu, 1oiy, 1ogu, 1p5e, 1pkd, 1h1p, 1h1q, 1h1r, 1h1s, 4cfx, 4cfv, 4cfu, 4cfm - hCYCA2 +CDK2 T160P+inhibitor
    
  • 1fin - hCYCA2 +CDK2
    
  • 1vyw - hCYCA2 C-terminal + hCDK2
    
  • 1jst, 3tnw - hCYCA2 +CDK2 T160P
    
  • 1h24, 1h25, 1h26, 1h27, 1h28, 1gy3 - hCYCA2 +CDK2 T160P+peptide
    
  • 4bck, 4bcm, 4bcn, 4bco, 4bcp, 4bcq, 4cfn, 4cfw - hCYCA2 +CDK2 T160P + inhibitor
    
  • 4fx3 - hCYCA2 +CDK2 + inhibitor
    
  • 4eoi, 4eoj, 4eok, 4eol, 4eom, 4eon, 4eoo, 4eop, 4eoq, 4eor, 4eos - hCYCA2 C-terminal +CDK2 T160P + inhibitor
    
  • 2cjm - hCYCA2 +CDK2 T160P Y15P
    
  • 2cch - hCYCA2 +CDK2 T160P+ATP analog
    
  • 4i3z, 4ii5 - hCYCA2 +CDK2 T160P+ADP + Mg
    
  • 2cci - hCYCA2 +CDK2 T160P+CDC homolog
    
  • 2wma, 2wmb, 2x1n, 2wev, 2wfy, 2whb, 1okv, 1okw, 1ol1, 1ol2, 1urc, 1qmz, 3qhw - hCYCA2 +CDK2+peptide
    
  • 1jsu - hCYCA2 +CDK2 (mutant)+P27
    
  • 3qhr, 3khw - CYCA2 + P33 protein kinase + CDK2 peptide – mouse
• CYCA3
  • 1vin – CYCA3 - bovine
    
  • 1e9h – hCYCA3 +CDK2 T160P+inhibitor
    
• CYCB1
  • 2b9r – hCYCB1 (mutant)
    
  • 2jgz - hCYCB1 +CDK2
• CYCC
  • 3rgf, 4g6l – hCYCC + CDK8
    
  • 4f6s, 4f6u, 4f6w, 4f70, 4f7j, 4f7l, 4f7n, 4f7s – hCYCC + CDK8 + inhibitor
    
• CYCD
  • 2w96, 2w99, 2w9f, 2w9z - hCYCD1 +CDK4 (mutant)
    
  • 3g33 – hCYCD3 +CDK4
• CYCE
  • 1w98 – hCYCE1 +CDK2 T160P
• CYCH
  • 1kxu, 1jkw – hCYCH
• CYCK
  • 2i53 – hCYCK N-terminal
    
  • 4un0 - hCYCK + CDK12 T160P
    
  • 4cxa - hCYCK + CDK12 T160P + AMPPNP
    
  • 4cjy - hCYCK +CDK12 T160P+inhibitor
    
• CYCT
  • 3blh - hCYCT1 +CDK9
    
  • 3blq - hCYCT1 +CDK9+ATP
    
  • 4imy - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4
    
  • 3lq5, 3tn8, 3tnh, 3tni, 4bcf, 4bcg, 4bch, 4bci, 4bcj – hCYCT1 (mutant)+CDK9
    
  • 3blr - hCYCT1 +CDK9+inhibitor
    
  • 3my1, 4ec8, 4ec9 - hCYCT1 (mutant)+CDK9 TPO160 +inhibitor
    
  • 3mi9, 3mia - hCYCT1 +CDK9+protein TAT
    
  • 2w2h - CYCT1 +protein TAT + RNA – horse
    
  • 2ivx – hCYCT2 (mutant)
• CYC
  • 2pk9 – yCYC PHO80 +CDK PHO85 – yeast
    
  • 2pmi - yCYC PHO80 +CDK PHO85+ATPgS
• Viral CYC
  • 2euf, 2f2c, 2xo2, 1jow – V-CYC viral+hCDK6 – Herpesvirus
    
  • 1bu2 – V-CYC
    
  • 1xo2 - V-CYC + hCDK6 + inhibitor
    
  • 1g3n - V-CYC viral+hCDK6+CDK6 inhibitor
    
  • 1f5q - V-CYC g viral+hCDK2

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