2v61 | pdb_00002v61
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| 2v61, resolution 1.70Å | |||||||||||||
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| Sites: | AC1, AC2, AC3 and AC4 | ||||||||||||
| Ligands: | FAD and C18 | ||||||||||||
| Activity: | Amine oxidase (flavin-containing), with EC number 1.4.3.4 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR 7-(3-CHLOROBENZYLOXY)-4-(METHYLAMINO)METHYL-COUMARIN
Overview
Structures of human monoamine oxidase B (MAO B) in complex with safinamide and two coumarin derivatives, all sharing a common benzyloxy substituent, were determined by X-ray crystallography. These compounds competitively inhibit MAO B with Ki values in the 0.1-0.5 microM range that are 30-700-fold lower than those observed with MAO A. The inhibitors bind noncovalently to MAO B, occupying both the entrance and the substrate cavities and showing a similarly oriented benzyloxy substituent.
About this Structure
2V61 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs., Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A, J Med Chem. 2007 Nov 15;50(23):5848-52. Epub 2007 Oct 4. PMID:17915852
Page seeded by OCA on Thu Mar 20 18:43:27 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Amine oxidase (flavin-containing)
- Homo sapiens
- Single protein
- Binda, C.
- Caccia, C.
- Carotti, A.
- Edmondson, D E.
- Mattevi, A.
- Pisani, L.
- Salvati, P.
- Wang, J.
- C18
- FAD
- Fad
- Flavoprotein
- Human mao b structure
- Membrane
- Mitochondrion
- Neuroprotection
- Oxidoreductase
- Parkinson's disease
- Reversible inhibitor binding
- Safinamide
- Transmembrane
