2v8o | pdb_00002v8o

File:2v8o.gif

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2v8o, resolution 1.90Å
Activity:	Flavivirin, with EC number 3.4.21.91
Coordinates:	save as pdb, mmCIF, xml

STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS RNA HELICASE TO 1.9A RESOLUTION

Overview

Murray Valley encephalitis virus (MVEV), a mosquito-borne flavivirus endemic to Australia, is closely related to Japanese encephalitis virus and West Nile virus. Nonstructural protein 3 (NS3) is a multifunctional enzyme with serine protease and DEXH/D-box helicase domains, whose activity is central to flavivirus replication and is therefore a possible target for anti-flaviviral compounds. Cloning, purification, and crystal structure determination to 1.9 Angstrom resolution of the NS3 helicase of MVEV and characterization of its enzymatic activity is reported. Comparison with the structures of helicases from related viruses supports a possible mechanism of ATP hydrolysis-driven strand separation.

About this Structure

2V8O is a Single protein structure of sequence from Murray valley encephalitis virus. Full crystallographic information is available from OCA.

Reference

Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution., Mancini EJ, Assenberg R, Verma A, Walter TS, Tuma R, Grimes JM, Owens RJ, Stuart DI, Protein Sci. 2007 Oct;16(10):2294-300. PMID:17893366

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