4xru | pdb_00004xru

Structure of Pnkp1/Rnl/Hen1 complex

spinqualitylabelsall models 4xru, resolution 3.41Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4xru is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ATP, GOL, MES, MG, PO4, SAH NonStd Res: MSE Related: 4xrp Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Ribotoxins cleave essential RNAs for cell killing, and RNA repair neutralizes the damage inflicted by ribotoxins for cell survival. Here we report a new bacterial RNA repair complex that performs RNA repair linked to immunity. This new RNA repair complex is a 270-kDa heterohexamer composed of three proteins-Pnkp1, Rnl and Hen1-that are required to repair ribotoxin-cleaved RNA in vitro. The crystal structure of the complex reveals the molecular architecture of the heterohexamer as two rhomboid-shaped ring structures of Pnkp1-Rnl-Hen1 heterotrimer fused at the Pnkp1 dimer interface. The four active sites required for RNA repair are located on the inner rim of each ring. The architecture and the locations of the active sites of the Pnkp1-Rnl-Hen1 heterohexamer suggest an ordered series of repair reactions at the broken RNA ends that confer immunity to recurrent damage. Reconstitution and structure of a bacterial Pnkp1-Rnl-Hen1 RNA repair complex.,Wang P, Selvadurai K, Huang RH Nat Commun. 2015 Apr 17;6:6876. doi: 10.1038/ncomms7876. PMID:25882814 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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