4ui1 | pdb_00004ui1

Crystal structure of the human RGMC-BMP2 complex

spinqualitylabelsall models 4ui1, resolution 2.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ui1 is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, EDO, NO3 Related: 4uhy, 4uhz, 4ui0, 4ui2 Resources: FirstGlance, OCA, RCSB, PDBsum Disease [RGMC_HUMAN] Hemochromatosis type 2. The disease is caused by mutations affecting the gene represented in this entry. Function [BMP2_HUMAN] Induces cartilage and bone formation. [RGMC_HUMAN] Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.[UniProtKB:Q7TQ32]

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