Template:STRUCTURE 1f5v
Nitroreductase (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO2 group. The NO2 group is reduced to hydroxylamine. NR use FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. The NR is of special interest due to its potential use as activator of prodrugs in cancer therapy.
3D structures of nitroreductase
Updated on 07-May-2015
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- Nitroreductase
- 1f5v, 1oo5 – EcNR – Escherichia coli
- 3bm1, 1ds7 – EcNR minimal
- 3bm2 – EcNR minimal -FMN
- 1nec, 1kqd – EclNR – Enterobacter cloacae
- 1ywq, 2i7h – NR – Bacillus cereus
- 2b67 – NR – Streptococcus pneumonia
- 3ek3, 3hoi – NR – Bacterioides fragilis
- 3g14 – NR – Clostridium novyi
- 3h4o, 3koq - NR – Clostridium difficile
- 3gr3 – NR – Bartonella henselae
- 3hzn – NR – Salmonella typhimurium
- 3k6h – NR – Agrobacterium tumefaciens
- 2wzv, 2ymv – MsNR – Mycobacterium smegmatis
- 3of4 – NR FMN/FAD – Idiomarina loihiensis
- 3n2s – NR – Bacillus subtilis
- 3pxv – NR – Desulfitobacterium hafniense
- 3qdl – NR – Helicobacter pylori
- 3r5l, 3r5p - MtNR – Mycobacterium tuberculosis
- 3r5r, 3r5w – MtNR F420
- 3ge6 – NR – Exiguobacterium sibiricum
- 4dn2 – NR – Geobacter metallireducens
- Copper-induced nitroreductase
- 2wqf – LlNR – Lactococcus lactis
- 4bn6 – LlNR + chloramphenicol
- 4bn7, 4bn8 – LlNR + phenol derivative
- 4bn9 – LlNR + nicotinic acid
- 4bnb – LlNR + nitroquinoline
- Nitroreductase binary complex
