Template:STRUCTURE 2yz8
Obscurin (Obs) or KIAA1556 is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.
Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see Group:MUZIC:Obscurin.
3D structures of obscurin
07-May-2015
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- Obscurin
- 2e7b - hObs 6th Ig domain residues 8-97 – human - NMR
- 2dm7 - hObs 14th Ig domain residues 1157-1251 – NMR
- 2gqh - hObs 15th Ig domain residues 1253-1346 – NMR
- 2eny - hObs Ig domain residues 2735-2825 – NMR
- 2edf - hObs 2nd Ig domain residues 2826-2915 – NMR
- 2dku - hObs Ig domain residues 2915-3004 – NMR
- 2cr6 - hObs Ig domain residues 2998-3100 – NMR
- 2yz8 - hObs 32nd Ig domain residues 3184-3273
- 2edr - hObs Ig domain residues 3361-3449 – NMR
- 2edt - hObs Ig domain residues 3449-3537 – NMR
- 2edw - hObs I-set domain residues 3537-3630 – NMR
- 2edh – hObs PDZ domain residues 3614-3713 – NMR
- 2edq - hObs Ig domain residues 3713-3806 – NMR
- 2edl - hObs Ig domain residues 3801-3897 – NMR
- 1v1c - hObs SH3 domain residues 5601-5668 – NMR
- Obscurin-like protein 1
- 2e6q - hObsL Ig domain residues 615-713 – NMR
- 2e6p - hObsL Ig domain residues 714-804 – NMR
- 3knb, 2wp3, 2wwm, 4c4k – hObs N terminal residues 1-105 + titin M10 domain
- 4uow - hObs residues 26829-26925+ titin M10 domain
- 2wwk – hObs N terminal residues 1-105 (mutant) + titin M10 domain
