4g5d | pdb_00004g5d

X-ray crystal structure of Prostaglandin f synthase from Leishmania major Friedlin bound to NADPH

spinqualitylabelsall models 4g5d, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4g5d is a 2 chain structure with sequence from Leishmania major mhom/il/81/friedlin. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NDP Related: 4f40 Gene: PGFS, LMJF_31_2150 (Leishmania major MHOM/IL/81/Friedlin) Activity: Prostaglandin-F synthase, with EC number 1.1.1.188 Resources: FirstGlance, OCA, RCSB, PDBsum Function [PGFS_LEIMA] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. Publication Abstract from PubMed The crystal structures of prostaglandin F synthase (PGF) from both Leishmania major and Trypanosoma cruzi with and without their cofactor NADP have been determined to resolutions of 2.6 A for T. cruzi PGF, 1.25 A for T. cruzi PGF with NADP, 1.6 A for L. major PGF and 1.8 A for L. major PGF with NADP. These structures were determined by molecular replacement to a final R factor of less than 18.6% (Rfree of less than 22.9%). PGF in the infectious protozoa L. major and T. cruzi is a potential therapeutic target. Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.,Moen SO, Fairman JW, Barnes SR, Sullivan A, Nakazawa-Hewitt S, Van Voorhis WC, Staker BL, Lorimer DD, Myler PJ, Edwards TE Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):609-14. doi:, 10.1107/S2053230X15006883. Epub 2015 Apr 21. PMID:25945716 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Prostaglandin F synthase

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