4zlf | pdb_00004zlf

Cellobionic acid phosphorylase - cellobionic acid complex

spinqualitylabelsall models 4zlf, resolution 1.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4zlf is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CEZ, CL, GOL, SO4 Related: 4zle, 4zlg, 4zli Activity: Cellobionic acid phosphorylase, with EC number 2.4.1.321 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed A novel phosphorylase was characterized as new member of glycoside hydrolase family 94 from the cellulolytic bacterium Xanthomonas campestris and the fungus Neurospora crassa. The enzyme catalyzed reversible phosphorolysis of cellobionic acid. We propose 4-O-beta-D-glucopyranosyl-D-gluconic acid: phosphate alpha-D-glucosyltransferase as the systematic name and cellobionic acid phosphorylase as the short names for the novel enzyme. Several cellulolytic fungi of the phylum Ascomycota also possess homologous proteins. We, therefore, suggest that the enzyme plays a crucial role in cellulose degradation where cellobionic acid as oxidized cellulolytic product is converted into alpha-D-glucose 1-phosphate and D-gluconic acid to enter glycolysis and the pentose phosphate pathway, respectively. Discovery of cellobionic acid phosphorylase in cellulolytic bacteria and fungi.,Nihira T, Saito Y, Nishimoto M, Kitaoka M, Igarashi K, Ohtsubo K, Nakai H FEBS Lett. 2013 Nov 1;587(21):3556-61. doi: 10.1016/j.febslet.2013.09.014. Epub, 2013 Sep 19. PMID:24055472 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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