4k7q | pdb_00004k7q

Crystal Structure of AcrB Complexed with Linezolid at 3.5 Resolution

spinqualitylabelsall models 4k7q, resolution 3.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4k7q is a 1 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ZLD Gene: acrB, acrE, b0462, JW0451 (ECOLI) Resources: FirstGlance, OCA, RCSB, PDBsum Function [ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity. Publication Abstract from PubMed AcrB is an inner membrane resistance-nodulation-cell division efflux pump and is part of the AcrAB-TolC tripartite efflux system. We have determined the crystal structure of AcrB with bound Linezolid at a resolution of 3.5 A. The structure shows that Linezolid binds to the A385/F386 loops of the symmetric trimer of AcrB. A conformational change of a loop in the bottom of the periplasmic cleft is also observed. Crystal structure of AcrB complexed with linezolid at 3.5 A resolution.,Hung LW, Kim HB, Murakami S, Gupta G, Kim CY, Terwilliger TC J Struct Funct Genomics. 2013 Jun;14(2):71-5. doi: 10.1007/s10969-013-9154-x., Epub 2013 May 15. PMID:23673416 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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