2ktu | pdb_00002ktu

Human eRF1 C-domain, "closed" conformer

spinqualitylabelsall models 2ktu, 24 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2ktu is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 2hst, 1dt9, 2ktv Gene: ETF1, ERF1, RF1, SUP45L1 (HUMAN) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Function [ERF1_HUMAN] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed We report NMR assignments of the protein backbone of the C-terminal domain (163 a.a.) of human class 1 translation termination factor eRF1. It was found that several protein loop residues exist in two slowly interconverting conformational states. NMR assignments of the C-terminal domain of human polypeptide release factor eRF1.,Mantsyzov AB, Ivanova EV, Birdsall B, Kolosov PM, Kisselev LL, Polshakov VI Biomol NMR Assign. 2007 Dec;1(2):183-5. Epub 2007 Oct 30. PMID:19636860 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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