2ht6 | pdb_00002ht6
Crystal structure of Human Gem G-domain bound to GDP
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| 2ht6, resolution 2.400Å | |||||||||||||
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| Ligands: | MG and GDP | ||||||||||||
| Gene: | GEM, KIR (Homo sapiens) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Overview
Gem, a member of the Rad,Gem/Kir subfamily of small G-proteins, has unique sequence features. We report here the crystallographic structure determination of the Gem G-domain in complex with nucleotide to 2.4 A resolution. Although the basic Ras protein fold is maintained, the Gem switch regions emphatically differ from the Ras paradigm. Our ensuing biochemical characterization indicates that Gem G-domain markedly prefers GDP over GTP. Two known functions of Gem are distinctly affected by spatially separated clusters of mutations.
Disease
Known diseases associated with this structure: Long QT syndrome-7 OMIM:[600681], Short QT syndrome-3 OMIM:[600681]
About this Structure
2HT6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure-function studies of the G-domain from human gem, a novel small G-protein., Opatowsky Y, Sasson Y, Shaked I, Ward Y, Chomsky-Hecht O, Litvak Y, Selinger Z, Kelly K, Hirsch JA, FEBS Lett. 2006 Oct 30;580(25):5959-64. Epub 2006 Oct 6. PMID:17052716
Page seeded by OCA on Sun Mar 23 15:17:10 2008
